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Comprar Haloperidol Unia (Brand name: Haldol) Online

  • €1.20
  • Brand name: Haldol
  • Disponibilidad: En stock
  • Ingrediente activo: Haloperidol
Haloperidol Unia es utilizado para el tratamiento de la esquizofrenia.
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10 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €4.58 €137.33
60 píldoras €3.73 €274.66 €223.73
90 píldoras €3.45 €412.00 €310.12
120 píldoras €3.30 €549.33 €396.51
180 píldoras €3.16 €823.99 €569.31
270 píldoras €3.07 €1,235.99 €828.49
360 píldoras €3.02 €1,647.98 €1,087.67
5 mg
Nombre del producto Por píldora Por paquete  
60 píldoras €2.38 €142.63
90 píldoras €2.06 €213.95 €185.71
120 píldoras €1.91 €285.27 €228.78
180 píldoras €1.75 €427.90 €314.93
270 píldoras €1.65 €641.85 €444.16
360 píldoras €1.59 €855.80 €573.37
1.5 mg
Nombre del producto Por píldora Por paquete  
60 píldoras €1.79 €107.17
90 píldoras €1.55 €160.75 €139.53
120 píldoras €1.43 €214.33 €171.90
180 píldoras €1.31 €321.50 €236.62
270 píldoras €1.24 €482.25 €333.73
360 píldoras €1.20 €643.00 €430.82

Drug Name

Haloperidol Unia (Haloperidol) 

Drug Uses

Haloperidol Unia is used for treating schizophrenia. It is also used to control symptoms associated with Tourette disorder. It also may be used for other conditions as determined by your doctor. 

How to use

Use Haloperidol Unia as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Haloperidol Unia is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Haloperidol Unia at home, a health care provider will teach you how to use it. Be sure you understand how to use Haloperidol Unia.
Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Do not use Haloperidol Unia if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Drug Class and Mechanism

Haloperidol Unia is an antipsychotic agent. Exactly how it works is not known, but it may work by blocking certain chemicals in the brain.
 
Missed Dose

If you miss a dose of Haloperidol Unia, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. 

Storage

Store Haloperidol Unia at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Haloperidol Unia out of the reach of children and away from pets.

Warnings/Precautions

Do not use Haloperidol Unia if: 
you are allergic to any ingredient in Haloperidol Unia;
you are in a coma, have Parkinson disease, or have severe central nervous system depression;
you are taking dofetilide, an H1 antagonist (e.g., astemizole, terfenadine), or sodium oxybate (GHB).
Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Haloperidol Unia . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have the blood disease porphyria, electrolyte problems (eg, low blood magnesium, low blood potassium), or a history of dementia, Alzheimer disease, seizures, or thyroid problems
if you have heart problems or irregular heartbeat (eg, QT prolongation), or if a member of your family has a history of these conditions

Some MEDICINES MAY INTERACT with Haloperidol Unia . Tell your health care provider if you are taking any other medicines, especially any of the following: 
Cisapride, dofetilide, H1 antagonists (eg, astemizole, terfenadine), macrolides or ketolides (eg, erythromycin, telithromycin), phenothiazines (eg, thioridazine), or pimozide because the risk of serious heart-related side effects may be increased
Lithium because the risk of unexpected toxic effects, including weakness, severe tiredness, confusion, or unusual muscle movements, may be increased
Rifampin because it may decrease Haloperidol Unia 's effectiveness. Carbamazepine because side effects of Haloperidol Unia may be increased or the effectiveness of Haloperidol Unia may be decreased
Anticoagulants (eg, warfarin) or sodium oxybate (GHB) because their actions and the risk of their side effects may be increased by Haloperidol Unia

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome: 
blurred vision; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; stomach upset; trouble sleeping.
Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; decreased urination; difficulty speaking or swallowing; drooling; excessive or unusual sweating; fainting; fast or irregular heartbeat; fever; hallucinations; mental or mood changes (e.g., abnormal thinking, agitation, anxiety, depression); prolonged, painful erection; rigid or stiff muscles; seizures; severe or persistent dizziness, headache, or vomiting; shuffling walk; uncontrolled muscle movements (e.g., of the arms, legs, tongue, jaw, cheeks; twitching; tremors); vision problems or changes; yellowing of skin or eyes.

More Information

Haloperidol Unia is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

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Type Small Molecule
Accession Number DB00502  (APRD00538)
Groups Approved
Synonyms
  • 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
  • 4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
  • 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
  • 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
  • 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
  • Haloperidolum
  • γ-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone
UNII J6292F8L3D
CAS number 52-86-8
Weight Average: 375.864
Monoisotopic: 375.140134897
Chemical Formula C21H23ClFNO2
InChI
InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
IUPAC Name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Protein binding

Haloperidol circulates in the blood bound predominantly (90-94%) to plasma proteins [7].

Toxicity

Acute oral toxicity (LD50): 71 mg/kg in rats [MSDS].

Toxicity of haloperidol may be divided into several categories, according the FDA label:

Cardiovascular Effects

The incidence of sudden death, QT-prolongation, and Torsades de Pointes has been reported in patients treated with this drug. Higher than usual doses of any formulation and intravenous (IV) administration of haloperidol have shown to be associated with a higher risk of QT-prolongation and Torsades de Pointes [Label].

Caution is advised in treating patients with other cardiac QT-prolonging conditions (including electrolyte imbalance [particularly hypokalemia and hypomagnesemia], drugs which prolong the QT interval, underlying cardiac abnormalities, hypothyroidism, and familial long QT-syndrome). Depot haloperidol is not to be administered by the IV route [Label].

Extrapyramidal Symptoms

Extrapyramidal symptoms are comprised of a group of movement disorders which may include dystonia, akathisia, tardive dyskinesia and parkinsonism. Drug-induced extrapyramidal symptoms have been common knowledge for decades, yet the use of these drugs is still common. Despite this, these symptoms may prove to be long-lasting, and therefore, caution is warranted in the prevention of extrapyramidal symptoms [13].

Tardive Dyskinesia

This is a consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs and is known as an extrapyramidal symptom [Label]. Although the prevalence of the syndrome appears to be high among the elderly, this is a particularly common occurrence in elderly women [Label]

The risk of developing tardive dyskinesia and the risk that it may be irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient over time. However, the syndrome can develop, although much less commonly, after brief periods of treatment at lower doses [Label].

There are no known treatments for established cases of tardive dyskinesia. The syndrome may remit, partially or completely, if antipsychotic treatment is removed [Label].

Antipsychotic drugs should be prescribed in a manner that is most likely to minimize the occurrence of If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics, drug discontinuation should be considered. However, some patients may require treatment despite the presence of the syndrome [Label].

Neuroleptic Malignant Syndrome (NMS)

A potentially fatal condition, sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been demonstrated in association with antipsychotic drugs treatment. Clinical signs and symptoms of NMS are hyperpyrexia, muscle rigidity, alterations in mental status (including catatonia) and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias). Other signs include elevated creatine phosphokinase (CPK), myoglobinuria (rhabdomyolysis) and acute kidney failure [Label].

General

In addition to the above toxicities, number of cases of bronchopneumonia, some fatal, have followed the use of antipsychotic drugs, including haloperidol. One theory suggests that lethargy and decreased sensation of thirst due to central inhibition may lead to dehydration, hemoconcentration and reduced pulmonary ventilation. Therefore, if the above signs and symptoms appear, especially in the elderly, the physician should institute remedial therapy promptly.

Hematologic Effects

Reports have been made of the occurrence of mild, usually transient leukopenia and leukocytosis, minimal decreases in red blood cell counts, anemia, or a tendency toward monocytosis. Agranulocytosis has rarely been reported to have occurred with the use of haloperidol, and then only in association with other medication [Label].

Liver Effects

Impaired liver function and/or jaundice may occur.

Dermatologic Reactions

Maculopapular and acne-like skin reactions and isolated cases of photosensitivity and loss of hair.

Endocrine Disorders

Lactation, breast engorgement, mastalgia, menstrual irregularities, gynecomastia, impotence, increased libido, hyperglycemia, hypoglycemia and hyponatremia [Label]

Gastrointestinal Effects

Anorexia, constipation, diarrhea, hypersalivation, dyspepsia, nausea and vomiting [Label]

Autonomic Reactions

Dry mouth, blurred vision, urinary retention, diaphoresis and priapism [Label]

Respiratory Effects

Laryngospasm, bronchospasm and increased depth of respiration [Label]

Special Senses

Cataracts, retinopathy and visual disturbances [Label]

Half life

For the non-decanoate formulations, the haloperidol half-life is on average 24 hours after oral administration and 21 hours after intramuscular administration [17].

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